BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival*
Identifieur interne : 000815 ( Main/Exploration ); précédent : 000814; suivant : 000816BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival*
Auteurs : Dianbo Qu ; Ali Hage ; Katie Don-Carolis ; En Huang ; Alvin Joselin ; Farzaneh Safarpour ; Paul C. Marcogliese ; Maxime W. C. Rousseaux ; Sarah J. Hewitt ; Tianwen Huang ; Doo-Soon Im ; Steve Callaghan ; Danielle Dewar-Darch [Canada] ; Daniel Figeys [Canada] ; Ruth S. Slack ; David S. ParkSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2015.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (genetics), Adaptor Proteins, Signal Transducing (metabolism), Animals, Cell Survival, Mice, Mice, Mutant Strains, Mitochondria (genetics), Mitochondria (metabolism), Mitochondrial Degradation (genetics), Mitochondrial Membranes (metabolism), Molecular Chaperones (genetics), Molecular Chaperones (metabolism), Neurons (metabolism), Protein Kinases (genetics), Protein Kinases (metabolism), Protein Stability, Protein Transport, Signal Transduction, Ubiquitin-Protein Ligases (genetics), Ubiquitin-Protein Ligases (metabolism), Ubiquitination.
- MESH :
- chemical , genetics : Adaptor Proteins, Signal Transducing, Molecular Chaperones, Protein Kinases, Ubiquitin-Protein Ligases.
- chemical , metabolism : Adaptor Proteins, Signal Transducing, Molecular Chaperones, Protein Kinases, Ubiquitin-Protein Ligases.
- genetics : Mitochondria, Mitochondrial Degradation.
- metabolism : Mitochondria, Mitochondrial Membranes, Neurons.
- Animals, Cell Survival, Mice, Mice, Mutant Strains, Protein Stability, Protein Transport, Signal Transduction, Ubiquitination.
Abstract
Emerging evidence has demonstrated a growing genetic component in Parkinson disease (PD). For instance, loss-of-function mutations in
Url:
DOI: 10.1074/jbc.M115.677815
PubMed: 26538564
PubMed Central: 4683266
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000039
- to stream Pmc, to step Curation: 000039
- to stream Pmc, to step Checkpoint: 000350
- to stream PubMed, to step Corpus: 000351
- to stream PubMed, to step Curation: 000351
- to stream PubMed, to step Checkpoint: 000351
- to stream Ncbi, to step Merge: 001D65
- to stream Ncbi, to step Curation: 001D65
- to stream Ncbi, to step Checkpoint: 001D65
- to stream Main, to step Merge: 000816
- to stream Main, to step Curation: 000815
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Qu, Dianbo" sort="Qu, Dianbo" uniqKey="Qu D" first="Dianbo" last="Qu">Dianbo Qu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Hage, Ali" sort="Hage, Ali" uniqKey="Hage A" first="Ali" last="Hage">Ali Hage</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Don Carolis, Katie" sort="Don Carolis, Katie" uniqKey="Don Carolis K" first="Katie" last="Don-Carolis">Katie Don-Carolis</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Huang, En" sort="Huang, En" uniqKey="Huang E" first="En" last="Huang">En Huang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Joselin, Alvin" sort="Joselin, Alvin" uniqKey="Joselin A" first="Alvin" last="Joselin">Alvin Joselin</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Safarpour, Farzaneh" sort="Safarpour, Farzaneh" uniqKey="Safarpour F" first="Farzaneh" last="Safarpour">Farzaneh Safarpour</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Marcogliese, Paul C" sort="Marcogliese, Paul C" uniqKey="Marcogliese P" first="Paul C." last="Marcogliese">Paul C. Marcogliese</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Rousseaux, Maxime W C" sort="Rousseaux, Maxime W C" uniqKey="Rousseaux M" first="Maxime W. C." last="Rousseaux">Maxime W. C. Rousseaux</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Hewitt, Sarah J" sort="Hewitt, Sarah J" uniqKey="Hewitt S" first="Sarah J." last="Hewitt">Sarah J. Hewitt</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Huang, Tianwen" sort="Huang, Tianwen" uniqKey="Huang T" first="Tianwen" last="Huang">Tianwen Huang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Im, Doo Soon" sort="Im, Doo Soon" uniqKey="Im D" first="Doo-Soon" last="Im">Doo-Soon Im</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Callaghan, Steve" sort="Callaghan, Steve" uniqKey="Callaghan S" first="Steve" last="Callaghan">Steve Callaghan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Dewar Darch, Danielle" sort="Dewar Darch, Danielle" uniqKey="Dewar Darch D" first="Danielle" last="Dewar-Darch">Danielle Dewar-Darch</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Figeys, Daniel" sort="Figeys, Daniel" uniqKey="Figeys D" first="Daniel" last="Figeys">Daniel Figeys</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Slack, Ruth S" sort="Slack, Ruth S" uniqKey="Slack R" first="Ruth S." last="Slack">Ruth S. Slack</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26538564</idno><idno type="pmc">4683266</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683266</idno><idno type="RBID">PMC:4683266</idno><idno type="doi">10.1074/jbc.M115.677815</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000039</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000039</idno><idno type="wicri:Area/Pmc/Curation">000039</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000039</idno><idno type="wicri:Area/Pmc/Checkpoint">000350</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000350</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000351</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000351</idno><idno type="wicri:Area/PubMed/Curation">000351</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000351</idno><idno type="wicri:Area/PubMed/Checkpoint">000351</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000351</idno><idno type="wicri:Area/Ncbi/Merge">001D65</idno><idno type="wicri:Area/Ncbi/Curation">001D65</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D65</idno><idno type="wicri:doubleKey">0021-9258:2015:Qu D:bag:gene:mediated</idno><idno type="wicri:Area/Main/Merge">000816</idno><idno type="wicri:Area/Main/Curation">000815</idno><idno type="wicri:Area/Main/Exploration">000815</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Qu, Dianbo" sort="Qu, Dianbo" uniqKey="Qu D" first="Dianbo" last="Qu">Dianbo Qu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Hage, Ali" sort="Hage, Ali" uniqKey="Hage A" first="Ali" last="Hage">Ali Hage</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Don Carolis, Katie" sort="Don Carolis, Katie" uniqKey="Don Carolis K" first="Katie" last="Don-Carolis">Katie Don-Carolis</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Huang, En" sort="Huang, En" uniqKey="Huang E" first="En" last="Huang">En Huang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Joselin, Alvin" sort="Joselin, Alvin" uniqKey="Joselin A" first="Alvin" last="Joselin">Alvin Joselin</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Safarpour, Farzaneh" sort="Safarpour, Farzaneh" uniqKey="Safarpour F" first="Farzaneh" last="Safarpour">Farzaneh Safarpour</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Marcogliese, Paul C" sort="Marcogliese, Paul C" uniqKey="Marcogliese P" first="Paul C." last="Marcogliese">Paul C. Marcogliese</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Rousseaux, Maxime W C" sort="Rousseaux, Maxime W C" uniqKey="Rousseaux M" first="Maxime W. C." last="Rousseaux">Maxime W. C. Rousseaux</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Hewitt, Sarah J" sort="Hewitt, Sarah J" uniqKey="Hewitt S" first="Sarah J." last="Hewitt">Sarah J. Hewitt</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Huang, Tianwen" sort="Huang, Tianwen" uniqKey="Huang T" first="Tianwen" last="Huang">Tianwen Huang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Im, Doo Soon" sort="Im, Doo Soon" uniqKey="Im D" first="Doo-Soon" last="Im">Doo-Soon Im</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Callaghan, Steve" sort="Callaghan, Steve" uniqKey="Callaghan S" first="Steve" last="Callaghan">Steve Callaghan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Dewar Darch, Danielle" sort="Dewar Darch, Danielle" uniqKey="Dewar Darch D" first="Danielle" last="Dewar-Darch">Danielle Dewar-Darch</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Figeys, Daniel" sort="Figeys, Daniel" uniqKey="Figeys D" first="Daniel" last="Figeys">Daniel Figeys</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Slack, Ruth S" sort="Slack, Ruth S" uniqKey="Slack R" first="Ruth S." last="Slack">Ruth S. Slack</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author><author><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Brain and Mind Research Institute</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (genetics)</term><term>Adaptor Proteins, Signal Transducing (metabolism)</term><term>Animals</term><term>Cell Survival</term><term>Mice</term><term>Mice, Mutant Strains</term><term>Mitochondria (genetics)</term><term>Mitochondria (metabolism)</term><term>Mitochondrial Degradation (genetics)</term><term>Mitochondrial Membranes (metabolism)</term><term>Molecular Chaperones (genetics)</term><term>Molecular Chaperones (metabolism)</term><term>Neurons (metabolism)</term><term>Protein Kinases (genetics)</term><term>Protein Kinases (metabolism)</term><term>Protein Stability</term><term>Protein Transport</term><term>Signal Transduction</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>Ubiquitin-Protein Ligases (metabolism)</term><term>Ubiquitination</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Molecular Chaperones</term><term>Protein Kinases</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Molecular Chaperones</term><term>Protein Kinases</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mitochondria</term><term>Mitochondrial Degradation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mitochondria</term><term>Mitochondrial Membranes</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Survival</term><term>Mice</term><term>Mice, Mutant Strains</term><term>Protein Stability</term><term>Protein Transport</term><term>Signal Transduction</term><term>Ubiquitination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Emerging evidence has demonstrated a growing genetic component in Parkinson disease (PD). For instance, loss-of-function mutations in <italic>PINK1</italic> or <italic>PARKIN</italic> can cause autosomal recessive PD. Recently, PINK1 and PARKIN have been implicated in the same signaling pathway to regulate mitochondrial clearance through recruitment of PARKIN by stabilization of PINK1 on the outer membrane of depolarized mitochondria. The precise mechanisms that govern this process remain enigmatic. In this study, we identify Bcl2-associated athanogene 2 (BAG2) as a factor that promotes mitophagy. BAG2 inhibits PINK1 degradation by blocking the ubiquitination pathway. Stabilization of PINK1 by BAG2 triggers PARKIN-mediated mitophagy and protects neurons against 1-methyl-4-phenylpyridinium-induced oxidative stress in an <italic>in vitro</italic> cell model of PD. Collectively, our findings support the notion that BAG2 is an upstream regulator of the PINK1/PARKIN signaling pathway.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Callaghan, Steve" sort="Callaghan, Steve" uniqKey="Callaghan S" first="Steve" last="Callaghan">Steve Callaghan</name><name sortKey="Don Carolis, Katie" sort="Don Carolis, Katie" uniqKey="Don Carolis K" first="Katie" last="Don-Carolis">Katie Don-Carolis</name><name sortKey="Hage, Ali" sort="Hage, Ali" uniqKey="Hage A" first="Ali" last="Hage">Ali Hage</name><name sortKey="Hewitt, Sarah J" sort="Hewitt, Sarah J" uniqKey="Hewitt S" first="Sarah J." last="Hewitt">Sarah J. Hewitt</name><name sortKey="Huang, En" sort="Huang, En" uniqKey="Huang E" first="En" last="Huang">En Huang</name><name sortKey="Huang, Tianwen" sort="Huang, Tianwen" uniqKey="Huang T" first="Tianwen" last="Huang">Tianwen Huang</name><name sortKey="Im, Doo Soon" sort="Im, Doo Soon" uniqKey="Im D" first="Doo-Soon" last="Im">Doo-Soon Im</name><name sortKey="Joselin, Alvin" sort="Joselin, Alvin" uniqKey="Joselin A" first="Alvin" last="Joselin">Alvin Joselin</name><name sortKey="Marcogliese, Paul C" sort="Marcogliese, Paul C" uniqKey="Marcogliese P" first="Paul C." last="Marcogliese">Paul C. Marcogliese</name><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name><name sortKey="Qu, Dianbo" sort="Qu, Dianbo" uniqKey="Qu D" first="Dianbo" last="Qu">Dianbo Qu</name><name sortKey="Rousseaux, Maxime W C" sort="Rousseaux, Maxime W C" uniqKey="Rousseaux M" first="Maxime W. C." last="Rousseaux">Maxime W. C. Rousseaux</name><name sortKey="Safarpour, Farzaneh" sort="Safarpour, Farzaneh" uniqKey="Safarpour F" first="Farzaneh" last="Safarpour">Farzaneh Safarpour</name><name sortKey="Slack, Ruth S" sort="Slack, Ruth S" uniqKey="Slack R" first="Ruth S." last="Slack">Ruth S. Slack</name></noCountry><country name="Canada"><noRegion><name sortKey="Dewar Darch, Danielle" sort="Dewar Darch, Danielle" uniqKey="Dewar Darch D" first="Danielle" last="Dewar-Darch">Danielle Dewar-Darch</name></noRegion><name sortKey="Figeys, Daniel" sort="Figeys, Daniel" uniqKey="Figeys D" first="Daniel" last="Figeys">Daniel Figeys</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000815 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000815 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4683266
|texte= BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival*
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26538564" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |